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Design of DNA Origami-Heparin Nanostructures for the Development of Viral Therapies

Authors :

Sadegh Dastorani¹ Mahmoud Shariati² Reza Hasanzadeh Ghasemi³

1- Ferdowsi University of Mashhad, Department of Mechanical Engineering 2- Ferdowsi University of Mashhad, Department of Mechanical Engineering 3- Hakim Sabzevari University,Department of Mechanical and Aerospace Engineering

Keywords :

Virus،DNA Origami،heparin،Linker

Abstract :

Given the increasing prevalence of viral diseases and limitations of current treatments, the development of a new generation of highly effective antiviral drugs with fewer side effects is imperative. This research introduces novel nanostructures based on DNA origami, heparin, and a spermidine-containing linker, which show great potential for targeted drug delivery and the treatment of viral diseases. These nanostructures form stable complexes, enabling efficient transport of antiviral drugs to infected cells. Additionally, the unique properties of these nanostructures make them a promising platform for the development of new antiviral drugs. The results of this study present a promising outlook for the development of a new generation of nanotechnology-based antiviral therapies.

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