سمپوزیوم منطقه ای نوآوری در علم و فناوری

English

صفحه اصلی / دومین سمپوزیوم منطقه ای نوآوری در علم و فناوری

Assessment of the Therapeutic Efficacy of Nanocapsules of Albendazol and Mebendazole against hydatidosis in BALB/c Mice

نویسندگان :

Nooshinmehr Soleymani¹ Hassan Borji² Abbas Rahdar³

1- دانشگاه فردوسی مشهد 2- دانشگاه فردوسی مشهد 3- دانشگاه زابل

کلمات کلیدی :

Nanotechnology،Nano capsule،Hydatidosis،Albendazole،Mebendazole

چکیده :

Using nanotechnology, medicine can effectively be made stronger, lighter, more durable, more reactive. In this study, a highly safe emulsion Nano-capsule was tested for its superior efficacy, the ability to overcome drug resistance, and the least possible amount of side effects and complications associated with the treatment of hydatidosis. Nano-capsules are synthesized using a micro-emulsion of oil in water. formulations were tested via droplet size, zeta potential and SEM. Following seven months after infection, hydatidosis-infected 30 mice were divided into three groups. Groups 1 was treated daily with Albendazole plus Mebendazole Polymer Nano-capsules (Nano-ABZ+MBZ), group 2 was treated with Albendazole plus Mebendazole (ABZ+MBZ) as a positive control group, and Albendazole as a control group, group 3 was the negative control group without treatments (only received PBS). According to the results of the study, the total cyst numbers, total cyst size and weight of Nano-ABZ+MBZ had significantly lower total cyst numbers than the ABZ+MBZ. As well as the cyst with the maximum size and highest weight of Nano-capsule group had significantly lower than control groups. In conclusion. ABZ+MBZ-Nano-capsule can serve as suitable alternatives to chemical drugs. With the right application of nanotechnology, it is possible to possess the potential to produce safe and effective drugs, which has promising implications.

لیست مقالات

لیست مقالات بایگانی شده

SEROLOGICAL AND MOLECULAR DETECTION OF HIGHLY PATHOGENIC AVIAN INFLUENZA OF LAYER HENS CIRCULATING IN DIYALA GOVERNORATE

Zainab Abd Awan Al-Talabani

تولید و توسعه نرم‌افزار شبیه‌ساز آموزش اپراتور واحد شیرین‌سازی گاز طبیعی

امید صباغ - میثم وحیدی فردوسی - محمدعلی فنایی شیخ الاسلامی

Investigation of the effect of electrolyte type in the anodizing process of titanium

Nazanin Yazdanparast - ّFaezeh Darvishian Haghighi

Monte Carlo modelling of Siemens Artiste linac head and the 160 MLC and assessment of dose maps for IMRT and 3D-CRT plans

Hashem Miri-Hakimabad - Elie Hoseinian-Azghadi - Laleh Rafat-Motavalli - Taylan Tuğrul - Niloofar Rafat-Motavalli - Vida Khodabandeh-Baygi - Mahdieh Dayyani

بررسی ساختار سلولی و بافت شناسی چشم طوطی ماهی در خلیج فارس

فائزه اخگراندوز - مجید عسکری حصنی

Develop a computational code to build three-dimensional fractal Discrete fracture network (FDFN)

Mahin Etemadifar - Gholamreza Shoaei - Morteza Javadi - Arash Hashemnejad

Design of DNA Origami-Heparin Nanostructures for the Development of Viral Therapies

Sadegh Dastorani - Mahmoud Shariati - Reza Hasanzadeh Ghasemi

Separation of Term-Preterm Birth from Non-pregnant Using Frequency and Nonlinear Analysis of Electrohysterogram Signals

Maryam Khansari - Maryam Khansari - Maryam Khansari

Patching methods of cardiac patches for treatment of myocardial infarction

Elham Sadat Rahimi - Zeinab Neshati

Impact of thickness, work function of electrodes for configuration of (Zno/Cs2AgBi0.75Sb0.25/ Spiro-OMeTAD ) perovskites solar cells

Murtadha Jameel Edam - Hawraa Mohammed Khadier - Dhuha Emad Tarek - Baraa Hadi Auad

بیشتر

ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها - نگارش 42.2.1