Regional Symposium on Innovation in science and technology

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A Multi-scale Monte Carlo Simulation on Gold Nanoparticle Dose Enhancement for a Lung Tumor Treated with I-125 Brachytherapy

Authors :

Elahe Movahedizade¹ Zahra Sajjadi²

1- دانشگاه پیام نور مشهد 2- دانشگاه پیام نورمشهد

Keywords :

Brachytherapy،Lung cancer،Nanoparticles،Monte carlo simulation،Geant4

Abstract :

It has been shown that the addition of gold nanoparticles in the tumor can improve the treatment gain in radiation therapy. In the present study, the dose enhancement ratio caused by I-125 Brachytherapy seeds with the presence of 3, 5, and 7 mg/g gold nanoparticles has been evaluated. The simulations were carried out on both macroscopic and microscopic scales using Geant4 and Geant4-DNA Monte Carlo toolkits, respectively. In both simulation scales, increasing the concentration of gold nanoparticles resulted in a dose enhancement of up to nearly 75%. Simulation results were similar at both macroscopic and microscopic scales when gold nanoparticles were physically defined, as opposed to when only tumor and cell densities were increased by the presence of nanoparticles. Direct and indirect DNA damage per primary photon also increased by raising the concentration of gold nanoparticles. In conclusion, the combination of gold nanoparticles with I-125 brachytherapy will be a promising approach for the treatment of lung tumors.